Thrombopoietin (THPO)

About Thrombopoietin

Thrombopoietin (THPO) is a protein from Homo sapiens identified by UniProt accession P40225, 353 residues long. MolForge cross-references it against 0 known binders and 321 disease associations.

Target properties

Protein name	Thrombopoietin
UniProt accession	P40225
Gene	THPO
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (321)

Diseases linked to this target (Open Targets).

essential thrombocythemia · score 0.73
platelet crit · score 0.66
platelet count · score 0.65
Thrombocytopenia · score 0.47
congenital amegakaryocytic thrombocytopenia · score 0.46
genetic disorder · score 0.41
familial thrombocytosis · score 0.37
hereditary isolated aplastic anemia · score 0.37
hereditary thrombocytosis with transverse limb defect · score 0.37
neutrophil count · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40225-F1	alphafold	PREDICTED	61.43	—

Amino-acid sequence (353 residues)

MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS QEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards