T-complex protein 1 subunit zeta (CCT6A)

About T-complex protein 1 subunit zeta

T-complex protein 1 subunit zeta (CCT6A) is a protein from Homo sapiens identified by UniProt accession P40227, 531 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	T-complex protein 1 subunit zeta
UniProt accession	P40227
Gene	CCT6A
Organism	Homo sapiens
Length	531 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
lung adenocarcinoma · score 0.28
glioblastoma multiforme · score 0.26
head and neck squamous cell carcinoma · score 0.25
endometrial cancer · score 0.25
esophageal cancer · score 0.25
gastric adenocarcinoma · score 0.25
breast adenocarcinoma · score 0.25
urinary bladder cancer · score 0.24
creatinine measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40227-F1	alphafold	PREDICTED	89.88	—

Amino-acid sequence (531 residues)

MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards