About Thrombopoietin receptor
Thrombopoietin receptor (MPL) is a protein
from Homo sapiens identified by UniProt accession
P40238, 635 residues long.
MolForge cross-references it against 0 known binders and
587 disease associations.
Target properties
| Protein name | Thrombopoietin receptor |
|---|
| UniProt accession | P40238 |
|---|
| Gene | MPL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 635 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (587)
Diseases linked to this target (Open Targets).
- congenital amegakaryocytic thrombocytopenia 1 · score 0.79
- thrombocythemia 2 · score 0.77
- primary myelofibrosis · score 0.73
- essential thrombocythemia · score 0.72
- Thrombocytopenia · score 0.71
- congenital amegakaryocytic thrombocytopenia · score 0.67
- platelet count · score 0.65
- familial thrombocytosis · score 0.64
- autoimmune thrombocytopenic purpura · score 0.62
- platelet crit · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40238-F1 | alphafold | PREDICTED | 72.71 | — |
Amino-acid sequence (635 residues)
MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC FWDEEEAAPS GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE VRLFFPLHLW VKNVFLNQTR TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL QISWEEPAPE ISDFLRYELR YGPRDPKNST GPTVIQLIAT ETCCPALQRP HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS CLISGLQPGN SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS RCHFKSRNDS IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE ISSGHLELEW QHPSSWAAQE TCYQLRYTGE GHQDWKVLEP PLGARGGTLE LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP TRVETATETA WISLVTALHL VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG QYLRDTAALS PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP
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