Proteasome subunit beta type-10 (PSMB10)

About Proteasome subunit beta type-10

Proteasome subunit beta type-10 (PSMB10) is a protein from Homo sapiens identified by UniProt accession P40306, 273 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	Proteasome subunit beta type-10
UniProt accession	P40306
Gene	PSMB10
Organism	Homo sapiens
Length	273 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (295)

Diseases linked to this target (Open Targets).

proteasome-associated autoinflammatory syndrome 5 · score 0.63
HIV infection · score 0.46
breast adenocarcinoma · score 0.30
glioblastoma multiforme · score 0.28
head and neck squamous cell carcinoma · score 0.28
body fat percentage · score 0.17
mean corpuscular volume · score 0.10
multiple myeloma · score 0.09
neoplasm · score 0.09
severe combined immunodeficiency due to CARD11 deficiency · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40306-F1	alphafold	PREDICTED	90.94	—

Amino-acid sequence (273 residues)

MLKPALEPRG GFSFENCQRN ASLERVLPGL KVPHARKTGT TIAGLVFQDG VILGADTRAT NDSVVADKSC EKIHFIAPKI YCCGAGVAAD AEMTTRMVAS KMELHALSTG REPRVATVTR ILRQTLFRYQ GHVGASLIVG GVDLTGPQLY GVHPHGSYSR LPFTALGSGQ DAALAVLEDR FQPNMTLEAA QGLLVEAVTA GILGDLGSGG NVDACVITKT GAKLLRTLSS PTEPVKRSGR YHFVPGTTAV LTQTVKPLTL ELVEETVQAM EVE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards