von Hippel-Lindau disease tumor suppressor (VHL)

About von Hippel-Lindau disease tumor suppressor

von Hippel-Lindau disease tumor suppressor (VHL) is a protein from Homo sapiens identified by UniProt accession P40337, 213 residues long. MolForge cross-references it against 0 known binders and 784 disease associations.

Target properties

Protein name	von Hippel-Lindau disease tumor suppressor
UniProt accession	P40337
Gene	VHL
Organism	Homo sapiens
Length	213 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (784)

Diseases linked to this target (Open Targets).

von Hippel-Lindau disease · score 0.89
Chuvash polycythemia · score 0.80
adrenal gland pheochromocytoma · score 0.76
Chuvash erythrocytosis · score 0.76
clear cell renal carcinoma · score 0.65
nonpapillary renal cell carcinoma · score 0.63
primary familial polycythemia due to EPO receptor mutation · score 0.58
hereditary neoplastic syndrome · score 0.57
Inherited cancer-predisposing syndrome · score 0.57
papillary renal cell carcinoma · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40337-F1	alphafold	PREDICTED	84.41	—

Amino-acid sequence (213 residues)

MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards