All-trans-retinol dehydrogenase [NAD(+)] ADH7 (ADH7)

About All-trans-retinol dehydrogenase [NAD(+)] ADH7

All-trans-retinol dehydrogenase [NAD(+)] ADH7 (ADH7) is a protein from Homo sapiens identified by UniProt accession P40394, 386 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	All-trans-retinol dehydrogenase [NAD(+)] ADH7
UniProt accession	P40394
Gene	ADH7
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.40
upper aerodigestive tract neoplasm · score 0.32
high altitude adaptation · score 0.26
glioblastoma multiforme · score 0.16
alcohol dependence measurement · score 0.15
cutaneous melanoma · score 0.12
vitamin D measurement · score 0.10
alcohol consumption measurement · score 0.10
triglyceride measurement · score 0.10
bitter alcoholic beverage consumption measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40394-F1	alphafold	PREDICTED	95.37	—

Amino-acid sequence (386 residues)

MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR IKILATGICR TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD KVIPLFLPQC RECNACRNPD GNLCIRSDIT GRGVLADGTT RFTCKGKPVH HFMNTSTFTE YTVVDESSVA KIDDAAPPEK VCLIGCGFST GYGAAVKTGK VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK FEKAMAVGAT ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK KFDLDQLITH VLPFKKISEG FELLNSGQSI RTVLTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards