About Pre-B-cell leukemia transcription factor 1
Pre-B-cell leukemia transcription factor 1 (PBX1) is a protein
from Homo sapiens identified by UniProt accession
P40424, 430 residues long.
MolForge cross-references it against 0 known binders and
399 disease associations.
Target properties
| Protein name | Pre-B-cell leukemia transcription factor 1 |
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| UniProt accession | P40424 |
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| Gene | PBX1 |
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| Organism | Homo sapiens |
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| Length | 430 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (399)
Diseases linked to this target (Open Targets).
- congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay · score 0.77
- congenital anomaly of kidney and urinary tract · score 0.47
- genetic disorder · score 0.44
- acute lymphoblastic leukemia · score 0.40
- myoepithelial tumor · score 0.37
- T-cell acute lymphoblastic leukemia · score 0.37
- breast ductal adenocarcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- B-cell acute lymphoblastic leukemia · score 0.37
- esophageal adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40424-F1 | alphafold | PREDICTED | 69.25 | — |
Amino-acid sequence (430 residues)
MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS ANGGWQDATT PSSVTSPTEG PGSVHSDTSN
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