Pre-B-cell leukemia transcription factor 2 (PBX2)

About Pre-B-cell leukemia transcription factor 2

Pre-B-cell leukemia transcription factor 2 (PBX2) is a protein from Homo sapiens identified by UniProt accession P40425, 430 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Pre-B-cell leukemia transcription factor 2
UniProt accession	P40425
Gene	PBX2
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
Parkinson disease · score 0.28
multiple sclerosis · score 0.28
Alzheimer disease · score 0.28
lysosomal storage disease · score 0.28
wet macular degeneration · score 0.16
atrophic macular degeneration · score 0.16
age-related macular degeneration · score 0.16
blood protein measurement · score 0.16
coronary artery disease · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40425-F1	alphafold	PREDICTED	69.03	—

Amino-acid sequence (430 residues)

MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards