Pre-B-cell leukemia transcription factor 3 (PBX3)

About Pre-B-cell leukemia transcription factor 3

Pre-B-cell leukemia transcription factor 3 (PBX3) is a protein from Homo sapiens identified by UniProt accession P40426, 434 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.

Target properties

Protein name	Pre-B-cell leukemia transcription factor 3
UniProt accession	P40426
Gene	PBX3
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (173)

Diseases linked to this target (Open Targets).

diet measurement · score 0.41
systolic blood pressure · score 0.39
Opioid use measurement · score 0.38
X-linked cone-rod dystrophy · score 0.36
dentures · score 0.35
caudate nucleus volume · score 0.34
pulse pressure measurement · score 0.29
dental caries · score 0.28
age-related hearing impairment · score 0.26
chronic obstructive pulmonary disease · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40426-F1	alphafold	PREDICTED	69.56	—

Amino-acid sequence (434 residues)

MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards