ADP-ribosylation factor-like protein 1 (ARL1)

About ADP-ribosylation factor-like protein 1

ADP-ribosylation factor-like protein 1 (ARL1) is a protein from Homo sapiens identified by UniProt accession P40616, 181 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	ADP-ribosylation factor-like protein 1
UniProt accession	P40616
Gene	ARL1
Organism	Homo sapiens
Length	181 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
neuroinflammatory disorder · score 0.37
lysosomal storage disease · score 0.33
Parkinson disease · score 0.33
multiple sclerosis · score 0.33
Alzheimer disease · score 0.33
alcohol dependence · score 0.11
age at onset · score 0.11
monocyte count · score 0.03
lymphocyte count · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40616-F1	alphafold	PREDICTED	92.25	—

Amino-acid sequence (181 residues)

MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG FNVETVTYKN LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI GISKSELVAM LEEEELRKAI LVVFANKQDM EQAMTSSEMA NSLGLPALKD RKWQIFKTSA TKGTGLDEAM EWLVETLKSR Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards