About DNA mismatch repair protein Mlh1
DNA mismatch repair protein Mlh1 (MLH1) is a protein
from Homo sapiens identified by UniProt accession
P40692, 756 residues long.
MolForge cross-references it against 0 known binders and
860 disease associations.
Target properties
| Protein name | DNA mismatch repair protein Mlh1 |
|---|
| UniProt accession | P40692 |
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| Gene | MLH1 |
|---|
| Organism | Homo sapiens |
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| Length | 756 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (860)
Diseases linked to this target (Open Targets).
- Lynch syndrome · score 0.85
- Muir-Torre syndrome · score 0.75
- colorectal cancer · score 0.75
- colon carcinoma · score 0.74
- mismatch repair cancer syndrome 1 · score 0.74
- colorectal neoplasm · score 0.73
- colonic neoplasm · score 0.65
- endometrial carcinoma · score 0.64
- Constitutional mismatch repair deficiency syndrome · score 0.63
- neoplasm · score 0.61
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40692-F1 | alphafold | PREDICTED | 77.31 | — |
Amino-acid sequence (756 residues)
MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVI VKEGGLKLIQ IQDNGTGIRK EDLDIVCERF TTSKLQSFED LASISTYGFR GEALASISHV AHVTITTKTA DGKCAYRASY SDGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKILEVV GRYSVHNAGI SFSVKKQGET VADVRTLPNA STVDNIRSIF GNAVSRELIE IGCEDKTLAF KMNGYISNAN YSVKKCIFLL FINHRLVEST SLRKAIETVY AAYLPKNTHP FLYLSLEISP QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEMV KSTTSLTSSS TSGSSDKVYA HQMVRTDSRE QKLDAFLQPL SKPLSSQPQA IVTEDKTDIS SGRARQQDEE MLELPAPAEV AAKNQSLEGD TTKGTSEMSE KRGPTSSNPR KRHREDSDVE MVEDDSRKEM TAACTPRRRI INLTSVLSLQ EEINEQGHEV LREMLHNHSF VGCVNPQWAL AQHQTKLYLL NTTKLSEELF YQILIYDFAN FGVLRLSEPA PLFDLAMLAL DSPESGWTEE DGPKEGLAEY IVEFLKKKAE MLADYFSLEI DEEGNLIGLP LLIDNYVPPL EGLPIFILRL ATEVNWDEEK ECFESLSKEC AMFYSIRKQY ISEESTLSGQ QSEVPGSIPN SWKWTVEHIV YKALRSHILP PKHFTEDGNI LQLANLPDLY KVFERC
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