Peroxisomal biogenesis factor 19 (PEX19)

About Peroxisomal biogenesis factor 19

Peroxisomal biogenesis factor 19 (PEX19) is a protein from Homo sapiens identified by UniProt accession P40855, 299 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Peroxisomal biogenesis factor 19
UniProt accession	P40855
Gene	PEX19
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 12A (Zellweger) · score 0.76
Zellweger syndrome · score 0.75
neurodegenerative disease · score 0.50
peroxisome biogenesis disorder · score 0.46
genetic disorder · score 0.41
peroxisome biogenesis disorder, complementation group 7 · score 0.37
lysosomal storage disease · score 0.37
Zellweger spectrum disorders · score 0.33
peroxisome biogenesis disorder 1A (Zellweger) · score 0.17
cutaneous melanoma · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40855-F1	alphafold	PREDICTED	70.60	—

Amino-acid sequence (299 residues)

MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ NLLSKDVLYP SLKEITEKYP EWLQSHRESL PPEQFEKYQE QHSVMCKICE QFEAETPTDS ETTQKARFEM VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ASGEQCLIM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards