Malate dehydrogenase, mitochondrial (MDH2)

About Malate dehydrogenase, mitochondrial

Malate dehydrogenase, mitochondrial (MDH2) is a protein from Homo sapiens identified by UniProt accession P40926, 338 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.

Target properties

Protein name	Malate dehydrogenase, mitochondrial
UniProt accession	P40926
Gene	MDH2
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (203)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy, 51 · score 0.74
developmental and epileptic encephalopathy · score 0.54
genetic disorder · score 0.49
pheochromocytoma-paraganglioma · score 0.37
hereditary pheochromocytoma-paraganglioma · score 0.37
mean platelet volume · score 0.31
eosinophil count · score 0.30
low density lipoprotein cholesterol measurement · score 0.29
neutrophil count · score 0.27
myeloid white cell count · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40926-F1	alphafold	PREDICTED	93.47	—

Amino-acid sequence (338 residues)

MLSALARPAS AALRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH TPGVAADLSH IETKAAVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI VATLTAACAQ HCPEAMICVI ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLTALTGRI QEAGTEVVKA KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVKS QETECTYFST PLLLGKKGIE KNLGIGKVSS FEEKMISDAI PELKASIKKG EDFVKTLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards