About Trifunctional enzyme subunit alpha, mitochondrial
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) is a protein
from Homo sapiens identified by UniProt accession
P40939, 763 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Trifunctional enzyme subunit alpha, mitochondrial |
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| UniProt accession | P40939 |
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| Gene | HADHA |
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| Organism | Homo sapiens |
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| Length | 763 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (239)
Diseases linked to this target (Open Targets).
- long chain 3-hydroxyacyl-CoA dehydrogenase deficiency · score 0.84
- mitochondrial trifunctional protein deficiency · score 0.74
- genetic disorder · score 0.47
- neurodegenerative disease · score 0.39
- hypertrophic cardiomyopathy · score 0.37
- glioblastoma multiforme · score 0.19
- Red cell distribution width · score 0.12
- non-alcoholic fatty liver disease · score 0.09
- hepatocellular carcinoma · score 0.08
- glycogen storage disease VI · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40939-F1 | alphafold | PREDICTED | 92.42 | — |
Amino-acid sequence (763 residues)
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA VVRINSPNSK VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA GADINMLAAC KTLQEVTQLS QEAQRIVEKL EKSTKPIVAA INGSCLGGGL EVAISCQYRI ATKDRKTVLG TPEVLLGALP GAGGTQRLPK MVGVPAALDM MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL EEVAITFAKG LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK KNKFGAPQKD VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG QQQVFKGLND KVKKKALTSF ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC IFASNTSALP ISEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK DGPGFYTTRC LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS DMDSILASLK LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG DIGAVFGLGF PPCLGGPFRF VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL ADHANSPNKK FYQ
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