About Leptin
Leptin (LEP) is a protein
from Homo sapiens identified by UniProt accession
P41159, 167 residues long.
MolForge cross-references it against 0 known binders and
1,719 disease associations.
Target properties
| Protein name | Leptin |
|---|
| UniProt accession | P41159 |
|---|
| Gene | LEP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 167 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1719)
Diseases linked to this target (Open Targets).
- obesity due to congenital leptin deficiency · score 0.72
- BMI-adjusted leptin measurement · score 0.49
- leptin measurement · score 0.46
- type 2 diabetes mellitus · score 0.37
- high density lipoprotein cholesterol measurement · score 0.34
- body mass index · score 0.27
- self reported educational attainment · score 0.27
- interleukin-6 measurement · score 0.24
- mastiha supplement exposure measurement · score 0.24
- HbA1c measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41159-F1 | alphafold | PREDICTED | 81.11 | — |
Amino-acid sequence (167 residues)
MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
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