ETS translocation variant 5 (ETV5)

About ETS translocation variant 5

ETS translocation variant 5 (ETV5) is a protein from Homo sapiens identified by UniProt accession P41161, 510 residues long. MolForge cross-references it against 0 known binders and 510 disease associations.

Target properties

Protein name	ETS translocation variant 5
UniProt accession	P41161
Gene	ETV5
Organism	Homo sapiens
Length	510 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (510)

Diseases linked to this target (Open Targets).

body mass index · score 0.49
high density lipoprotein cholesterol measurement · score 0.48
glomerular filtration rate · score 0.45
physical activity measurement · score 0.45
creatinine measurement · score 0.43
smoking behavior · score 0.42
lean body mass · score 0.42
body fat percentage · score 0.41
fat body mass · score 0.39
serum alanine aminotransferase measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41161-F1	alphafold	PREDICTED	57.07	—

Amino-acid sequence (510 residues)

MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards