About Aquaporin-2
Aquaporin-2 (AQP2) is a protein
from Homo sapiens identified by UniProt accession
P41181, 271 residues long.
MolForge cross-references it against 0 known binders and
351 disease associations.
Target properties
| Protein name | Aquaporin-2 |
|---|
| UniProt accession | P41181 |
|---|
| Gene | AQP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 271 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (351)
Diseases linked to this target (Open Targets).
- diabetes insipidus, nephrogenic, autosomal · score 0.82
- nephrogenic diabetes insipidus · score 0.68
- neurodegenerative disease · score 0.43
- allergic rhinitis · score 0.25
- asthma · score 0.25
- allergic disease · score 0.24
- genetic disorder · score 0.19
- nephrotic syndrome · score 0.09
- chronic kidney disease · score 0.08
- cyst · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41181-F1 | alphafold | PREDICTED | 91.73 | — |
Amino-acid sequence (271 residues)
MWELRSIAFS RAVFAEFLAT LLFVFFGLGS ALNWPQALPS VLQIAMAFGL GIGTLVQALG HISGAHINPA VTVACLVGCH VSVLRAAFYV AAQLLGAVAG AALLHEITPA DIRGDLAVNA LSNSTTAGQA VTVELFLTLQ LVLCIFASTD ERRGENPGTP ALSIGFSVAL GHLLGIHYTG CSMNPARSLA PAVVTGKFDD HWVFWIGPLV GAILGSLLYN YVLFPPAKSL SERLAVLKGL EPDTDWEERE VRRRQSVELH SPQSLPRGTK A
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