Transcription factor ETV6 (ETV6)

About Transcription factor ETV6

Transcription factor ETV6 (ETV6) is a protein from Homo sapiens identified by UniProt accession P41212, 452 residues long. MolForge cross-references it against 0 known binders and 515 disease associations.

Target properties

Protein name	Transcription factor ETV6
UniProt accession	P41212
Gene	ETV6
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (515)

Diseases linked to this target (Open Targets).

thrombocytopenia 5 · score 0.77
Thrombocytopenia · score 0.64
acute myeloid leukemia · score 0.63
cancer · score 0.60
acute lymphoblastic leukemia · score 0.54
T-cell acute lymphoblastic leukemia · score 0.51
body height · score 0.49
lean body mass · score 0.47
genetic disorder · score 0.46
hemoglobin measurement · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41212-F1	alphafold	PREDICTED	61.80	—

Amino-acid sequence (452 residues)

MSETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE GKPINLSHRE DLAYMNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW EDKESKIFRI VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM KTPDEIMSGR TDRLEHLESQ ELDEQIYQED EC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards