About Eukaryotic translation initiation factor 2D
Eukaryotic translation initiation factor 2D (EIF2D) is a protein
from Homo sapiens identified by UniProt accession
P41214, 584 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 2D |
|---|
| UniProt accession | P41214 |
|---|
| Gene | EIF2D |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- left atrial volume measurement · score 0.20
- monocyte percentage of leukocytes · score 0.19
- myeloid white cell count · score 0.04
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome · score 0.04
- immunodeficiency 75 · score 0.04
- glycoprotein storage disease · score 0.04
- neuronal ceroid lipofuscinosis 1 · score 0.04
- Hepatic veno-occlusive disease - immunodeficiency · score 0.04
- hemoglobin H disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41214-F1 | alphafold | PREDICTED | 76.04 | — |
Amino-acid sequence (584 residues)
MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK
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