Myeloid cell nuclear differentiation antigen (MNDA)

About Myeloid cell nuclear differentiation antigen

Myeloid cell nuclear differentiation antigen (MNDA) is a protein from Homo sapiens identified by UniProt accession P41218, 407 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Myeloid cell nuclear differentiation antigen
UniProt accession	P41218
Gene	MNDA
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

type 1 diabetes mellitus · score 0.25
mean corpuscular volume · score 0.19
inflammatory bowel disease · score 0.15
genetic disorder · score 0.12
acute myeloid leukemia · score 0.10
ovarian carcinoma · score 0.05
retinitis pigmentosa and erythrocytic microcytosis · score 0.04
hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.04
X-linked sideroblastic anemia 1 · score 0.04
hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41218-F1	alphafold	PREDICTED	77.85	—

Amino-acid sequence (407 residues)

MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards