Peripherin (PRPH)

About Peripherin

Peripherin (PRPH) is a protein from Homo sapiens identified by UniProt accession P41219, 470 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Peripherin
UniProt accession	P41219
Gene	PRPH
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

familial amyotrophic lateral sclerosis · score 0.59
sporadic amyotrophic lateral sclerosis · score 0.59
amyotrophic lateral sclerosis · score 0.35
prostate carcinoma · score 0.32
genetic disorder · score 0.19
mean platelet volume · score 0.14
platelet count · score 0.13
platelet component distribution width · score 0.12
frontotemporal dementia with motor neuron disease · score 0.12
axial length measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41219-F1	alphafold	PREDICTED	78.23	—

Amino-acid sequence (470 residues)

MSHHPSGLRA GFSSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSAS PSSSVRLGSF RSPRAGAGAL LRLPSERLDF SMAEALNQEF LATRSNEKQE LQELNDRFAN FIEKVRFLEQ QNAALRGELS QARGQEPARA DQLCQQELRE LRRELELLGR ERDRVQVERD GLAEDLAALK QRLEEETRKR EDAEHNLVLF RKDVDDATLS RLELERKIES LMDEIEFLKK LHEEELRDLQ VSVESQQVQQ VEVEATVKPE LTAALRDIRA QYESIAAKNL QEAEEWYKSK YADLSDAANR NHEALRQAKQ EMNESRRQIQ SLTCEVDGLR GTNEALLRQL RELEEQFALE AGGYQAGAAR LEEELRQLKE EMARHLREYQ ELLNVKMALD IEIATYRKLL EGEESRISVP VHSFASLNIK TTVPEVEPPQ DSHSRKTVLI KTIETRNGEV VTESQKEQRS ELDKSSAHSY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards