About Protein Wnt-5a
Protein Wnt-5a (WNT5A) is a protein
from Homo sapiens identified by UniProt accession
P41221, 380 residues long.
MolForge cross-references it against 0 known binders and
911 disease associations.
Target properties
| Protein name | Protein Wnt-5a |
|---|
| UniProt accession | P41221 |
|---|
| Gene | WNT5A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 380 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (911)
Diseases linked to this target (Open Targets).
- autosomal dominant Robinow syndrome · score 0.64
- Robinow syndrome · score 0.54
- body height · score 0.42
- appendicular lean mass · score 0.40
- lean body mass · score 0.36
- fat body mass · score 0.31
- endometrial cancer · score 0.23
- lung adenocarcinoma · score 0.19
- genetic disorder · score 0.19
- neuroimaging measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41221-F1 | alphafold | PREDICTED | 87.66 | — |
Amino-acid sequence (380 residues)
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK
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