Prostaglandin-H2 D-isomerase (PTGDS)

About Prostaglandin-H2 D-isomerase

Prostaglandin-H2 D-isomerase (PTGDS) is a protein from Homo sapiens identified by UniProt accession P41222, 190 residues long. MolForge cross-references it against 0 known binders and 309 disease associations.

Target properties

Protein name	Prostaglandin-H2 D-isomerase
UniProt accession	P41222
Gene	PTGDS
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (309)

Diseases linked to this target (Open Targets).

lysosomal storage disease · score 0.28
blood protein measurement · score 0.28
Parkinson disease · score 0.28
neurodegenerative disease · score 0.28
multiple sclerosis · score 0.28
Alzheimer disease · score 0.27
central corneal thickness · score 0.23
intraocular pressure measurement · score 0.21
corneal topography · score 0.16
keratoconus · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41222-F1	alphafold	PREDICTED	87.78	—

Amino-acid sequence (190 residues)

MATHHTLWMG LALLGVLGDL QAAPEAQVSV QPNFQQDKFL GRWFSAGLAS NSSWLREKKA ALSMCKSVVA PATDGGLNLT STFLRKNQCE TRTMLLQPAG SLGSYSYRSP HWGSTYSVSV VETDYDQYAL LYSQGSKGPG EDFRMATLYS RTQTPRAELK EKFTAFCKAQ GFTEDTIVFL PQTDKCMTEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards