About Hepatocyte nuclear factor 4-alpha
Hepatocyte nuclear factor 4-alpha (HNF4A) is a protein
from Homo sapiens identified by UniProt accession
P41235, 474 residues long.
MolForge cross-references it against 0 known binders and
541 disease associations.
Target properties
| Protein name | Hepatocyte nuclear factor 4-alpha |
|---|
| UniProt accession | P41235 |
|---|
| Gene | HNF4A |
|---|
| Organism | Homo sapiens |
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| Length | 474 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (541)
Diseases linked to this target (Open Targets).
- MODY · score 0.82
- type 2 diabetes mellitus · score 0.75
- maturity-onset diabetes of the young · score 0.71
- monogenic diabetes · score 0.68
- sex hormone-binding globulin measurement · score 0.66
- high density lipoprotein cholesterol measurement · score 0.55
- renal cysts and diabetes syndrome · score 0.54
- low density lipoprotein cholesterol measurement · score 0.53
- C-reactive protein measurement · score 0.52
- alcohol consumption measurement · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41235-F1 | alphafold | PREDICTED | 73.90 | — |
Amino-acid sequence (474 residues)
MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT NVIVANTMPT HLSNGQMCEW PRPRGQAATP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL SAIPQPTITK QEVI
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