About C->U-editing enzyme APOBEC-1
C->U-editing enzyme APOBEC-1 (APOBEC1) is a protein
from Homo sapiens identified by UniProt accession
P41238, 236 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | C->U-editing enzyme APOBEC-1 |
|---|
| UniProt accession | P41238 |
|---|
| Gene | APOBEC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 236 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.28
- apolipoprotein A 1 measurement · score 0.24
- blood protein measurement · score 0.23
- alcohol drinking · score 0.16
- cutaneous melanoma · score 0.14
- creatine kinase measurement · score 0.09
- pancreatic adenocarcinoma · score 0.08
- acute kidney failure · score 0.07
- hypertriglyceridemia 2 · score 0.07
- Barrett's esophagus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41238-F1 | alphafold | PREDICTED | 87.96 | — |
Amino-acid sequence (236 residues)
MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI REFLSRHPGV TLVIYVARLF WHMDQQNRQG LRDLVNSGVT IQIMRASEYY HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL ELHCIILSLP PCLKISRRWQ NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR
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