About Tyrosine-protein kinase CSK
Tyrosine-protein kinase CSK (CSK) is a protein
from Homo sapiens identified by UniProt accession
P41240, 450 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase CSK |
|---|
| UniProt accession | P41240 |
|---|
| Gene | CSK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 450 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (239)
Diseases linked to this target (Open Targets).
- cancer · score 0.60
- neurodegenerative disease · score 0.55
- Noonan syndrome · score 0.53
- hypertrophic cardiomyopathy · score 0.50
- Costello syndrome · score 0.50
- cardiofaciocutaneous syndrome · score 0.37
- diastolic blood pressure · score 0.32
- systolic blood pressure · score 0.30
- glioblastoma multiforme · score 0.30
- endometrial cancer · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41240-F1 | alphafold | PREDICTED | 91.21 | — |
Amino-acid sequence (450 residues)
MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL
Explore Tyrosine-protein kinase CSK with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets