About Glycine--tRNA ligase
Glycine--tRNA ligase (GARS1) is a protein
from Homo sapiens identified by UniProt accession
P41250, 739 residues long.
MolForge cross-references it against 0 known binders and
262 disease associations.
Target properties
| Protein name | Glycine--tRNA ligase |
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| UniProt accession | P41250 |
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| Gene | GARS1 |
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| Organism | Homo sapiens |
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| Length | 739 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (262)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 2D · score 0.77
- neuronopathy, distal hereditary motor, type 5A · score 0.75
- Autosomal dominant Charcot-Marie-Tooth disease type 2D · score 0.72
- Distal hereditary motor neuropathy type 5 · score 0.71
- spinal muscular atrophy, infantile, James type · score 0.65
- Charcot-Marie-Tooth disease type 2 · score 0.54
- Charcot-Marie-Tooth disease · score 0.48
- genetic disorder · score 0.34
- Tip-toe gait · score 0.26
- distal hereditary motor neuropathy · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41250-F1 | alphafold | PREDICTED | 86.12 | — |
Amino-acid sequence (739 residues)
MPSPRPVLLR GARAALLLLL PPRLLARPSL LLRRSLSAAS CPPISLPAAA SRSSMDGAGA EEVLAPLRLA VRQQGDLVRK LKEDKAPQVD VDKAVAELKA RKRVLEAKEL ALQPKDDIVD RAKMEDTLKR RFFYDQAFAI YGGVSGLYDF GPVGCALKNN IIQTWRQHFI QEEQILEIDC TMLTPEPVLK TSGHVDKFAD FMVKDVKNGE CFRADHLLKA HLQKLMSDKK CSVEKKSEME SVLAQLDNYG QQELADLFVN YNVKSPITGN DLSPPVSFNL MFKTFIGPGG NMPGYLRPET AQGIFLNFKR LLEFNQGKLP FAAAQIGNSF RNEISPRSGL IRVREFTMAE IEHFVDPSEK DHPKFQNVAD LHLYLYSAKA QVSGQSARKM RLGDAVEQGV INNTVLGYFI GRIYLYLTKV GISPDKLRFR QHMENEMAHY ACDCWDAESK TSYGWIEIVG CADRSCYDLS CHARATKVPL VAEKPLKEPK TVNVVQFEPS KGAIGKAYKK DAKLVMEYLA ICDECYITEM EMLLNEKGEF TIETEGKTFQ LTKDMINVKR FQKTLYVEEV VPNVIEPSFG LGRIMYTVFE HTFHVREGDE QRTFFSFPAV VAPFKCSVLP LSQNQEFMPF VKELSEALTR HGVSHKVDDS SGSIGRRYAR TDEIGVAFGV TIDFDTVNKT PHTATLRDRD SMRQIRAEIS ELPSIVQDLA NGNITWADVE ARYPLFEGQE TGKKETIEE
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