Neuroblastoma suppressor of tumorigenicity 1 (NBL1)

About Neuroblastoma suppressor of tumorigenicity 1

Neuroblastoma suppressor of tumorigenicity 1 (NBL1) is a protein from Homo sapiens identified by UniProt accession P41271, 181 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Neuroblastoma suppressor of tumorigenicity 1
UniProt accession	P41271
Gene	NBL1
Organism	Homo sapiens
Length	181 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

body mass index · score 0.29
cortical surface area measurement · score 0.28
leukocyte count · score 0.26
cortical thickness · score 0.26
neuroimaging measurement · score 0.26
brain measurement · score 0.25
body height · score 0.23
vital capacity · score 0.21
waist-hip ratio · score 0.20
refractive error measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41271-F1	alphafold	PREDICTED	75.76	—

Amino-acid sequence (181 residues)

MMLRVLVGAV LPAMLLAAPP PINKLALFPD KSAWCEAKNI TQIVGHSGCE AKSIQNRACL GQCFSYSVPN TFPQSTESLV HCDSCMPAQS MWEIVTLECP GHEEVPRVDK LVEKILHCSC QACGKEPSHE GLSVYVQGED GPGSQPGTHP HPHPHPHPGG QTPEPEDPPG APHTEEEGAE D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards