About Mitogen-activated protein kinase kinase kinase 8
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) is a protein
from Homo sapiens identified by UniProt accession
P41279, 467 residues long.
MolForge cross-references it against 0 known binders and
302 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 8 |
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| UniProt accession | P41279 |
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| Gene | MAP3K8 |
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| Organism | Homo sapiens |
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| Length | 467 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (302)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.42
- Crohn's disease · score 0.40
- C-reactive protein measurement · score 0.36
- neurodegenerative disease · score 0.33
- ulcerative colitis · score 0.30
- asthma · score 0.29
- psoriasis · score 0.28
- ankylosing spondylitis · score 0.28
- sclerosing cholangitis · score 0.28
- breast adenocarcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41279-F1 | alphafold | PREDICTED | 73.95 | — |
Amino-acid sequence (467 residues)
MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG PPTLEYG
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