About Reduced folate transporter
Reduced folate transporter (SLC19A1) is a protein
from Homo sapiens identified by UniProt accession
P41440, 591 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Reduced folate transporter |
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| UniProt accession | P41440 |
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| Gene | SLC19A1 |
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| Organism | Homo sapiens |
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| Length | 591 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (138)
Diseases linked to this target (Open Targets).
- Knobloch syndrome · score 0.55
- Knobloch syndrome 1 · score 0.52
- glaucoma, primary closed-angle · score 0.48
- Retinal dystrophy · score 0.46
- immunodeficiency 114, folate-responsive · score 0.45
- megaloblastic anemia, folate-responsive · score 0.45
- genetic disorder · score 0.41
- FEV/FVC ratio · score 0.39
- creatinine measurement · score 0.39
- cystatin C measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41440-F1 | alphafold | PREDICTED | 72.08 | — |
Amino-acid sequence (591 residues)
MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q
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