Eukaryotic translation initiation factor 1 (EIF1)

About Eukaryotic translation initiation factor 1

Eukaryotic translation initiation factor 1 (EIF1) is a protein from Homo sapiens identified by UniProt accession P41567, 113 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 1
UniProt accession	P41567
Gene	EIF1
Organism	Homo sapiens
Length	113 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

cerebrovascular disorder · score 0.09
hepatocellular carcinoma · score 0.04
ulcerative colitis · score 0.03
laryngotracheoesophageal cleft · score 0.02
Corpuscular Hemoglobin Content · score 0.02
Chédiak-Higashi syndrome · score 0.02
calf circumference measurement · score 0.02
pancreatic neoplasm · score 0.01
axial length measurement · score 0.01
cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41567-F1	alphafold	PREDICTED	80.52	—

Amino-acid sequence (113 residues)

MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards