About Pituitary adenylate cyclase-activating polypeptide type I receptor
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a protein
from Homo sapiens identified by UniProt accession
P41586, 468 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| UniProt accession | P41586 |
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| Gene | ADCYAP1R1 |
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| Organism | Homo sapiens |
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| Length | 468 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- DNA methylation · score 0.32
- gut microbiome measurement · score 0.28
- refractory celiac disease · score 0.26
- thyroid gland adenocarcinoma · score 0.25
- blood protein measurement · score 0.25
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- post-traumatic stress disorder · score 0.10
- low grade glioma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41586-F1 | alphafold | PREDICTED | 75.52 | — |
Amino-acid sequence (468 residues)
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT
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