Vasoactive intestinal polypeptide receptor 2 (VIPR2)

About Vasoactive intestinal polypeptide receptor 2

Vasoactive intestinal polypeptide receptor 2 (VIPR2) is a protein from Homo sapiens identified by UniProt accession P41587, 438 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Vasoactive intestinal polypeptide receptor 2
UniProt accession	P41587
Gene	VIPR2
Organism	Homo sapiens
Length	438 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

refractive error · score 0.48
refractive error measurement · score 0.43
Myopia · score 0.40
age at onset · score 0.37
Abnormality of refraction · score 0.32
bone density · score 0.30
urate measurement · score 0.30
pathological myopia · score 0.29
whooping cough · score 0.17
myoepithelial tumor · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41587-F1	alphafold	PREDICTED	74.32	—

Amino-acid sequence (438 residues)

MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK ACSGVWDNIT CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE TFPDFVDACG YSDPEDESKI TFYILVKAIY TLGYSVSLMS LATGSIILCL FRKLHCTRNY IHLNLFLSFI LRAISVLVKD DVLYSSSGTL HCPDQPSSWV GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS ISSKYQILFE LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards