About Protein kinase C iota type
Protein kinase C iota type (PRKCI) is a protein
from Homo sapiens identified by UniProt accession
P41743, 596 residues long.
MolForge cross-references it against 0 known binders and
160 disease associations.
Target properties
| Protein name | Protein kinase C iota type |
|---|
| UniProt accession | P41743 |
|---|
| Gene | PRKCI |
|---|
| Organism | Homo sapiens |
|---|
| Length | 596 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (160)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.50
- mast-cell leukemia · score 0.47
- neoplasm · score 0.42
- systemic mastocytosis · score 0.39
- Mastocytosis · score 0.37
- prostate carcinoma · score 0.37
- leukemia · score 0.29
- urinary albumin to creatinine ratio · score 0.25
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P41743-F1 | alphafold | PREDICTED | 80.30 | — |
Amino-acid sequence (596 residues)
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV
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