ETS domain-containing protein Elk-3 (ELK3)

About ETS domain-containing protein Elk-3

ETS domain-containing protein Elk-3 (ELK3) is a protein from Homo sapiens identified by UniProt accession P41970, 407 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	ETS domain-containing protein Elk-3
UniProt accession	P41970
Gene	ELK3
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
cortical surface area measurement · score 0.40
body height · score 0.34
brain measurement · score 0.32
B-cell acute lymphoblastic leukemia · score 0.31
lymphocyte count · score 0.27
neurofibrillary tangles measurement · score 0.23
small intestine neuroendocrine tumor · score 0.20
FEV/FVC ratio · score 0.14
arterial stiffness measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41970-F1	alphafold	PREDICTED	59.36	—

Amino-acid sequence (407 residues)

MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI SRESLLLQDS DCKASPEGRE AHKHGLAALR STSRNEYIHS GLYSSFTINS LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR TVIRFVTNKT DKHVTRPVVS LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS SRSPSLSPNS PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI HFWSSLSPVA PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL SSNSQKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards