Beta-centractin (ACTR1B)

About Beta-centractin

Beta-centractin (ACTR1B) is a protein from Homo sapiens identified by UniProt accession P42025, 376 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Beta-centractin
UniProt accession	P42025
Gene	ACTR1B
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

body mass index · score 0.27
alcohol consumption measurement · score 0.17
smoking status measurement · score 0.16
eosinophil count · score 0.16
Duane anomaly · score 0.15
Duane retraction syndrome · score 0.15
bitter alcoholic beverage consumption measurement · score 0.13
colorectal cancer · score 0.13
brain measurement · score 0.13
neuroimaging measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42025-F1	alphafold	PREDICTED	93.34	—

Amino-acid sequence (376 residues)

MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL DTFKKMWVSK KEYEEDGSRA IHRKTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards