T-lymphocyte activation antigen CD86 (CD86)

About T-lymphocyte activation antigen CD86

T-lymphocyte activation antigen CD86 (CD86) is a protein from Homo sapiens identified by UniProt accession P42081, 329 residues long. MolForge cross-references it against 0 known binders and 745 disease associations.

Target properties

Protein name	T-lymphocyte activation antigen CD86
UniProt accession	P42081
Gene	CD86
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (745)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.61
psoriatic arthritis · score 0.53
juvenile idiopathic arthritis · score 0.53
acute graft vs. host disease · score 0.50
immune system disease · score 0.46
COVID-19 · score 0.45
dermatomyositis · score 0.45
multiple sclerosis · score 0.43
eosinophil count · score 0.41
cancer · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42081-F1	alphafold	PREDICTED	80.06	—

Amino-acid sequence (329 residues)

MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK IHIPERSDEA QRVFKSSKTS SCDKSDTCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards