Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)

About Enoyl-CoA delta isomerase 1, mitochondrial

Enoyl-CoA delta isomerase 1, mitochondrial (ECI1) is a protein from Homo sapiens identified by UniProt accession P42126, 302 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Enoyl-CoA delta isomerase 1, mitochondrial
UniProt accession	P42126
Gene	ECI1
Organism	Homo sapiens
Length	302 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

body weights and measures · score 0.23
alkaline phosphatase measurement · score 0.21
body height · score 0.15
hypertriglyceridemia 2 · score 0.04
Red cell distribution width · score 0.03
neoplasm · score 0.02
hepatocellular carcinoma · score 0.01
psoriasis · score 0.01
polycystic ovary syndrome · score 0.01
juvenile dermatomyositis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42126-F1	alphafold	PREDICTED	89.63	—

Amino-acid sequence (302 residues)

MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE PDAGAGVAVM KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RYCIGLNETQ LGIIAPFWLK DTLENTIGHR AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI AQWMAIPDHA RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE KG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards