Agouti-signaling protein (ASIP)

About Agouti-signaling protein

Agouti-signaling protein (ASIP) is a protein from Homo sapiens identified by UniProt accession P42127, 132 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.

Target properties

Protein name	Agouti-signaling protein
UniProt accession	P42127
Gene	ASIP
Organism	Homo sapiens
Length	132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (201)

Diseases linked to this target (Open Targets).

sunburn · score 0.38
hair color · score 0.38
skin pigmentation · score 0.37
oculocutaneous albinism type 6 · score 0.35
heel bone mineral density · score 0.29
balding measurement · score 0.23
hair colour measurement · score 0.21
basal cell carcinoma · score 0.20
melanoma · score 0.19
cutaneous squamous cell carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42127-F1	alphafold	PREDICTED	66.64	—

Amino-acid sequence (132 residues)

MDVTRLLLAT LLVFLCFFTA NSHLPPEEKL RDDRSLRSNS SVNLLDVPSV SIVALNKKSK QIGRKAAEKK RSSKKEASMK KVVRPRTPLS APCVATRNSC KPPAPACCDP CASCQCRFFR SACSCRVLSL NC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards