About Rho GTPase-activating protein 25
Rho GTPase-activating protein 25 (ARHGAP25) is a protein
from Homo sapiens identified by UniProt accession
P42331, 645 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Rho GTPase-activating protein 25 |
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| UniProt accession | P42331 |
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| Gene | ARHGAP25 |
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| Organism | Homo sapiens |
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| Length | 645 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.50
- platelet count · score 0.46
- alkaline phosphatase measurement · score 0.45
- neutrophil count · score 0.44
- monocyte percentage of leukocytes · score 0.44
- bone density · score 0.43
- platelet crit · score 0.42
- lymphocyte percentage of leukocytes · score 0.42
- heel bone mineral density · score 0.41
- neutrophil percentage of leukocytes · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42331-F1 | alphafold | PREDICTED | 69.38 | — |
Amino-acid sequence (645 residues)
MSLKLPRNWD FNLKVEAAKI ARSRSVMTGE QMAAFHPSST PNPLERPIKM GWLKKQRSIV KNWQQRYFVL RAQQLYYYKD EEDTKPQGCM YLPGCTIKEI ATNPEEAGKF VFEIIPASWD QNRMGQDSYV LMASSQAEME EWVKFLRRVA GTPCGVFGQR LDETVAYEQK FGPHLVPILV EKCAEFILEH GRNEEGIFRL PGQDNLVKQL RDAFDAGERP SFDRDTDVHT VASLLKLYLR DLPEPVVPWS QYEGFLLCGQ LTNADEAKAQ QELMKQLSIL PRDNYSLLSY ICRFLHEIQL NCAVNKMSVD NLATVIGVNL IRSKVEDPAV IMRGTPQIQR VMTMMIRDHE VLFPKSKDIP LSPPAQKNDP KKAPVARSSV GWDATEDLRI SRTDSFSSMT SDSDTTSPTG QQPSDAFPED SSKVPREKPG DWKMQSRKRT QTLPNRKCFL TSAFQGANSS KMEIFKNEFW SPSSEAKAGE GHRRTMSQDL RQLSDSQRTS TYDNVPSLPG SPGEEASALS SQACDSKGDT LASPNSETGP GKKNSGEEEI DSLQRMVQEL RKEIETQKQM YEEQIKNLEK ENYDVWAKVV RLNEELEKEK KKSAALEISL RNMERSREDV EKRNKALEEE VKEFVKSMKE PKTEA
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