About Histidine ammonia-lyase
Histidine ammonia-lyase (HAL) is a protein
from Homo sapiens identified by UniProt accession
P42357, 657 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Histidine ammonia-lyase |
|---|
| UniProt accession | P42357 |
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| Gene | HAL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 657 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- histidinemia · score 0.68
- vitamin D measurement · score 0.65
- histidine measurement · score 0.57
- sunburn · score 0.37
- neurodegenerative disease · score 0.30
- vitamin D deficiency · score 0.30
- urinary metabolite measurement · score 0.30
- cutaneous melanoma · score 0.30
- keratinocyte carcinoma · score 0.29
- cutaneous squamous cell carcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42357-F1 | alphafold | PREDICTED | 90.93 | — |
Amino-acid sequence (657 residues)
MPRYTVHVRG EWLAVPCQDA QLTVGWLGRE AVRRYIKNKP DNGGFTSVDD AHFLVRRCKG LGLLDNEDRL EVALENNEFV EVVIEGDAMS PDFIPSQPEG VYLYSKYREP EKYIELDGDR LTTEDLVNLG KGRYKIKLTP TAEKRVQKSR EVIDSIIKEK TVVYGITTGF GKFARTVIPI NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEMFNAS CLPYVPEKGT VGASGDLAPL SHLALGLVGE GKMWSPKSGW ADAKYVLEAH GLKPVILKPK EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHALRPHRG QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKNIITT ELNSATDNPM VFANRGETVS GGNFHGEYPA KALDYLAIGI HELAAISERR IERLCNPSLS ELPAFLVAEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI EAAHRLLLEQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LQFLHKKSTK IPESEDL
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