About Protein AF-9
Protein AF-9 (MLLT3) is a protein
from Homo sapiens identified by UniProt accession
P42568, 568 residues long.
MolForge cross-references it against 0 known binders and
325 disease associations.
Target properties
| Protein name | Protein AF-9 |
|---|
| UniProt accession | P42568 |
|---|
| Gene | MLLT3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 568 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (325)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- glomerular filtration rate · score 0.42
- platelet component distribution width · score 0.41
- hemoglobin measurement · score 0.41
- hematocrit · score 0.41
- cortical surface area measurement · score 0.40
- serum gamma-glutamyl transferase measurement · score 0.39
- B-cell acute lymphoblastic leukemia · score 0.37
- protein measurement · score 0.36
- FEV change measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42568-F1 | alphafold | PREDICTED | 61.83 | — |
Amino-acid sequence (568 residues)
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK PLKEEKIVPK MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS TLPPFDDIVD PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ GPLRSIMKDL HSDDNEEESD EVEDNDNDSE MERPVNRGGS RSRRVSLSDG SDSESSSASS PLHHEPPPPL LKTNNNQILE VKSPIKQSKS DKQIKNGECD KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN TTFDFDLCSL DKTTVRKLQS YLETSGTS
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