Caspase-3 (CASP3)

About Caspase-3

Caspase-3 (CASP3) is a protein from Homo sapiens identified by UniProt accession P42574, 277 residues long. MolForge cross-references it against 0 known binders and 1,308 disease associations.

Target properties

Protein name	Caspase-3
UniProt accession	P42574
Gene	CASP3
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1308)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
mucocutaneous lymph node syndrome · score 0.45
head and neck squamous cell carcinoma · score 0.28
cutaneous melanoma · score 0.27
lung adenocarcinoma · score 0.26
hepatocellular carcinoma · score 0.21
acute myeloid leukemia · score 0.20
breast carcinoma · score 0.19
gastric carcinoma · score 0.19
urinary bladder carcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42574-F1	alphafold	PREDICTED	85.83	—

Amino-acid sequence (277 residues)

MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards