Caspase-2 (CASP2)

About Caspase-2

Caspase-2 (CASP2) is a protein from Homo sapiens identified by UniProt accession P42575, 452 residues long. MolForge cross-references it against 0 known binders and 193 disease associations.

Target properties

Protein name	Caspase-2
UniProt accession	P42575
Gene	CASP2
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (193)

Diseases linked to this target (Open Targets).

intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly · score 0.63
genetic disorder · score 0.49
blood protein measurement · score 0.28
breast adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.23
lung adenocarcinoma · score 0.23
gastric adenocarcinoma · score 0.23
endometrial cancer · score 0.23
cutaneous melanoma · score 0.13
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42575-F1	alphafold	PREDICTED	78.39	—

Amino-acid sequence (452 residues)

MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards