Small ribosomal subunit protein eS27 (RPS27)

About Small ribosomal subunit protein eS27

Small ribosomal subunit protein eS27 (RPS27) is a protein from Homo sapiens identified by UniProt accession P42677, 84 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Small ribosomal subunit protein eS27
UniProt accession	P42677
Gene	RPS27
Organism	Homo sapiens
Length	84 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Blackfan-Diamond anemia · score 0.45
COVID-19 · score 0.37
severe acute respiratory syndrome · score 0.37
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
neurodegenerative disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42677-F1	alphafold	PREDICTED	92.45	—

Amino-acid sequence (84 residues)

MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards