About Megakaryocyte-associated tyrosine-protein kinase
Megakaryocyte-associated tyrosine-protein kinase (MATK) is a protein
from Homo sapiens identified by UniProt accession
P42679, 507 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Megakaryocyte-associated tyrosine-protein kinase |
|---|
| UniProt accession | P42679 |
|---|
| Gene | MATK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 507 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (85)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- glioblastoma multiforme · score 0.24
- lung adenocarcinoma · score 0.23
- breast adenocarcinoma · score 0.21
- endometrial cancer · score 0.18
- energy expenditure · score 0.17
- head and neck squamous cell carcinoma · score 0.13
- low grade glioma · score 0.11
- neoplasm · score 0.05
- lymphocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42679-F1 | alphafold | PREDICTED | 83.76 | — |
Amino-acid sequence (507 residues)
MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR ELRSAGAPAS VSGQDADGST SPRSQEP
Explore Megakaryocyte-associated tyrosine-protein kinase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets