About Tyrosine-protein kinase Tec
Tyrosine-protein kinase Tec (TEC) is a protein
from Homo sapiens identified by UniProt accession
P42680, 631 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Tec |
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| UniProt accession | P42680 |
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| Gene | TEC |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (123)
Diseases linked to this target (Open Targets).
- alopecia areata · score 0.50
- platelet component distribution width · score 0.38
- rheumatoid arthritis · score 0.36
- Vitiligo · score 0.36
- pulse pressure measurement · score 0.30
- lung adenocarcinoma · score 0.21
- oral squamous cell carcinoma · score 0.18
- myelodysplastic syndrome · score 0.18
- gastric carcinoma · score 0.18
- breast carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42680-F1 | alphafold | PREDICTED | 85.02 | — |
Amino-acid sequence (631 residues)
MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR CWQEKPEGRP SFEDLLRTID ELVECEETFG R
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