About Tyrosine-protein kinase TXK
Tyrosine-protein kinase TXK (TXK) is a protein
from Homo sapiens identified by UniProt accession
P42681, 527 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase TXK |
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| UniProt accession | P42681 |
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| Gene | TXK |
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| Organism | Homo sapiens |
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| Length | 527 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (89)
Diseases linked to this target (Open Targets).
- alopecia areata · score 0.50
- mean platelet volume · score 0.40
- Vitiligo · score 0.36
- neurodegenerative disease · score 0.30
- multiple sclerosis · score 0.21
- platelet component distribution width · score 0.14
- rheumatoid arthritis · score 0.10
- lung adenocarcinoma · score 0.10
- Crohn's disease · score 0.07
- ulcerative colitis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42681-F1 | alphafold | PREDICTED | 79.54 | — |
Amino-acid sequence (527 residues)
MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH LGSYTISVFM GARRSTEAAI KHYQIKKNDS GQWYVAERHA FQSIPELIWY HQHNAAGLMT RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS EGFRLYRPHL APMSIYEVMY SCWHEKPEGR PTFAELLRAV TEIAETW
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