About Tyrosine-protein kinase FRK
Tyrosine-protein kinase FRK (FRK) is a protein
from Homo sapiens identified by UniProt accession
P42685, 505 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase FRK |
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| UniProt accession | P42685 |
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| Gene | FRK |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (208)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.58
- acute lymphoblastic leukemia · score 0.55
- metastatic colorectal cancer · score 0.54
- low density lipoprotein cholesterol measurement · score 0.51
- colorectal cancer · score 0.51
- neoplasm · score 0.50
- colorectal neoplasm · score 0.50
- total cholesterol measurement · score 0.49
- C-reactive protein measurement · score 0.48
- serum alanine aminotransferase measurement · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42685-F1 | alphafold | PREDICTED | 83.17 | — |
Amino-acid sequence (505 residues)
MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGALCSPQS QRHGHYFVAL FDYQARTAED LSFRAGDKLQ VLDTLHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA IGRSDAEKQL LYSENKTGSF LIRESESQKG EFSLSVLDGA VVKHYRIKRL DEGGFFLTRR RIFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI QLYAVCTLED PIYIITELMR HGSLQEYLQN DTGSKIHLTQ QVDMAAQVAS GMAYLESRNY IHRDLAARNV LVGEHNIYKV ADFGLARVFK VDNEDIYESR HEIKLPVKWT APEAIRSNKF SIKSDVWSFG ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF ETLRWKLEDY FETDSSYSDA NNFIR
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