About ATP-dependent RNA helicase with zinc finger domain
ATP-dependent RNA helicase with zinc finger domain (HELZ) is a protein
from Homo sapiens identified by UniProt accession
P42694, 1942 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase with zinc finger domain |
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| UniProt accession | P42694 |
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| Gene | HELZ |
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| Organism | Homo sapiens |
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| Length | 1942 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.38
- sex hormone-binding globulin measurement · score 0.37
- lymphocyte percentage of leukocytes · score 0.29
- Abnormal brain morphology · score 0.27
- antisocial behaviour measurement · score 0.26
- substance abuse · score 0.26
- attention deficit hyperactivity disorder · score 0.26
- neutrophil percentage of leukocytes · score 0.25
- apolipoprotein B measurement · score 0.22
- lifestyle measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42694-F1 | alphafold | PREDICTED | 58.79 | — |
Amino-acid sequence (1942 residues)
MEDRRAEKSC EQACESLKRQ DYEMALKHCT EALLSLGQYS MADFTGPCPL EIERIKIESL LYRIASFLQL KNYVQADEDC RHVLGEGLAK GEDAFRAVLC CMQLKGKLQP VSTILAKSLT GESLNGMVTK DLTRLKTLLS ETETATSNAL SGYHVEDLDE GSCNGWHFRP PPRGITSSEE YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQNENKQ LSGSYMETLI EKWMNSLSPE KVLSECIEGV KVEHNPDLSV TVSTKKSHQT WTFALTCKPA RMLYRVALLY DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKQQLV TTAKRWDSSS KTIIDFEPNE TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKSNYQSRL HDLLYIEEIA QYKEISKFNL KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTK VNAVYLLPVP KQKLVQTQGT KEKVYEATIE EKTKEYIFLR LSRECCEELN LRPDCDTQVE LQFQLNRLPL CEMHYALDRI KDNGVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAITTPLAIQ LPPVLIIGPY GTGKTFTLAQ AVKHILQQQE TRILICTHSN SAADLYIKDY LHPYVEAGNP QARPLRVYFR NRWVKTVHPV VHQYCLISSA HSTFQMPQKE DILKHRVVVV TLNTSQYLCQ LDLEPGFFTH ILLDEAAQAM ECETIMPLAL ATQNTRIVLA GDHMQLSPFV YSEFARERNL HVSLLDRLYE HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI GVVTPYADQV FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH TCKHKQTPIK KKEQLLEDST EDLDYGFLSN YKLLNTAITR AQSLVAVVGD PIALCSIGRC RKFWERFIAL CHENSSLHGI TFEQIKAQLE ALELKKTYVL NPLAPEFIPR ALRLQHSGST NKQQQSPPKG KSLHHTQNDH FQNDGIVQPN PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL QTHGRGSPIP YGLGHHPPVT IGQPQNQHQE KDQHEQNRNG KSDTNNSGPE INKIRTPEKK PTEPKQVDLE SNPQNRSPES RPSVVYPSTK FPRKDNLNPR HINLPLPAPH AQYAIPNRHF HPLPQLPRPP FPIPQQHTLL NQQQNNLPEQ PNQIPPQPNQ VVQQQSQLNQ QPQQPPPQLS PAYQAGPNNA FFNSAVAHRP QSPPAEAVIP EQQPPPMLQE GHSPLRAIAQ PGPILPSHLN SFIDENPSGL PIGEALDRIH GSVALETLRQ QQARFQQWSE HHAFLSQGSA PYPHHHHPHL QHLPQPPLGL HQPPVRADWK LTSSAEDEVE TTYSRFQDLI RELSHRDQSE TRELAEMPPP QSRLLQYRQV QSRSPPAVPS PPSSTDHSSH FSNFNDNSRD IEVASNPAFP QRLPPQIFNS PFSLPSEHLA PPPLKYLAPD GAWTFANLQQ NHLMGPGFPY GLPPLPHRPP QNPFVQIQNH QHAIGQEPFH PLSSRTVSSS SLPSLEEYEP RGPGRPLYQR RISSSSVQPC SEEVSTPQDS LAQCKELQDH SNQSSFNFSS PESWVNTTSS TPYQNIPCNG SSRTAQPREL IAPPKTVKPP EDQLKSENLE VSSSFNYSVL QHLGQFPPLM PNKQIAESAN SSSPQSSAGG KPAMSYASAL RAPPKPRPPP EQAKKSSDPL SLFQELSLGS SSGSNGFYSY FK
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